Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs
نویسندگان
چکیده
منابع مشابه
Anatomically shaped osteochondral constructs for articular cartilage repair.
Few successful treatment modalities exist for surface-wide, full-thickness lesions of articular cartilage. Functional tissue engineering offers a great potential for the clinical management of such lesions. Our long-term hypothesis is that anatomically shaped tissue constructs of entire articular layers can be engineered in vitro on a bony substrate, for subsequent implantation. To determine th...
متن کاملRepair of Porcine Articular Osteochondral Defects
Introduction: Our previous study showed that porcine articular osteochondral defects at non-weight bearing area could be repaired by autologous induced bone marrow stromal cells (BMSCs) and scaffold, which provided the direct evidence that BMSCs could differentiate into chondrocytes and osteoblasts respectively in different local environment . This study tests the possibility of repairing porci...
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Tissue engineering combined with gene therapy is a promising approach for promoting articular cartilage repair. Here, we tested the hypothesis that engineered cartilage with chondrocytes overexpressing a human insulin-like growth factor I (IGF-I) gene can enhance the repair of osteochondral defects, in a manner dependent on the duration of cultivation. Genetically modified chondrocytes were cul...
متن کاملRepair of osteochondral defects in rabbits with ectopically produced cartilage.
Cartilage has poor regenerative capacity. Donor site morbidity and interference with joint homeostasis should be considered when applying the autologous chondrocyte transplantation technique. The use of ectopically produced cartilage, derived from periosteum, might be a novel method to heal cartilage defects. Ectopic cartilage was produced by dissecting a piece of periosteum from the tibia of r...
متن کاملTissue Engineering of Articular Cartilage: Perichondrial Cells in Osteochondral Repair
Efforts to expand treatment options for articular cartilage repair have increasingly focused on the implantation of cell polymer constructs. Primary cells cultured from perichondrium, a chondrogenic tissue, were found to survive in vitro within a biodegradable porous polylactic acid matrix. These perichondrocyte-polylactic acid composite grafts were then implanted within osteochondral defects d...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2020
ISSN: 0006-3592,1097-0290
DOI: 10.1002/bit.27287